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SAN JOSE, Calif., Nov. 4, 2020 /PRNewswire/ - Anatomage Inc, a medical technology leader in 3D imaging technology, today announces the launch of a physiology section and other major updates.

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Invivo 5.4 row_user_manual_eng_rev_b_(um-inveu-eng-54_b) • 1. Invivo5.4 Reference Manual English Anatomage, Inc. 111 North Market Street Suite 500, San Jose, CA 95113 U.S.A. Tel) 408.885.1474 Fax) 408.295.9786 www.anatomage.com • I N V I V O 5. 4 ® – P I O N E E R I N G T H E N E W D I M E N S I O N O F P A T I E N T C A R E ™ ANA003 Rev B. 26 May 2015 Page 2 of 216 UM-INVEU-ENG-54B Warranty Statement There are no warranties, express or implied, with respect to the contents of this document, and all information provided herein is provided “as is.” Anatomage reserves the right to periodically change the information that is contained in this document; however, Anatomage makes no commitment to provide any such changes in a timely manner or at all.

Limitation of Liability In no event shall Anatomage or its affiliates be liable to any party for any direct, indirect, special, or consequential damages in connection with your use of this document, including, without limitation, loss of business revenue or earnings, lost data, damages caused by delays, lost profits, or a failure to realize expected savings, even if Anatomage was expressly advised of the possibility of such damages. End of Life Statement InVivoDental software is dependent on its hardware requirements. The life-cycle is limited only by the availability of the required hardware. Trademarks Anatomage and related marks, images, and symbols are the exclusive properties of, and trademarks of, Anatomage Inc.

All other brands and marks are the properties of their respective owners. Copyright Documentation for InVivoDental and the operating software are copyrighted with all rights reserved. Under the copyright laws, this documentation may not be reproduced, transmitted, transcribed, or translated into any human or computer language in whole or part without the prior written permission of the copyright holder.

About Anatomage and InVivoDental Software This version of InVivoDental was released as an update to the original InVivoDental software from Anatomage, Inc. In this document, InVivoDental refers to the latest version of the Anatomage InVivoDental software and is synonymous with the terms “Invivo” and “Invivo5.” To learn more about Anatomage, access the Anatomage website (www.Anatomage.com).

Intended User InVivoDental is designed to be used by medical and dental professionals who have been appropriately trained to use 3D CT imaging devices and read the image data generated by the devices. Language The original language of this manual is English. Other versions are available. Please contact Anatomage for other language versions.

Caution: Federal law restricts this device to sale by or on the order of medical and dental clinicians. • I N V I V O 5. 4 ® – P I O N E E R I N G T H E N E W D I M E N S I O N O F P A T I E N T C A R E ™ ANA003 Rev B. 26 May 2015 Page 3 of 216 UM-INVEU-ENG-54B Indications for Use InVivoDental is a software application used for the display and 3D visualization of medical image files from scanning devices, such as CT, MRI, or 3D Ultrasound. It is intended for use by radiologists, clinicians, referring physicians, and other qualified individuals to retrieve, process, render, review, store, print, assist in diagnosis and distribute images, utilizing standard PC hardware. Additionally, InVivoDental is a preoperative software application used for the simulation and evaluation of dental implants, orthodontic planning, and surgical treatments.

This device is not indicated for mammography use. • I N V I V O 5. 4 ® – P I O N E E R I N G T H E N E W D I M E N S I O N O F P A T I E N T C A R E ™ ANA003 Rev B. 26 May 2015 Page 4 of 216 UM-INVEU-ENG-54B Table of Contents Table of Contents................. 4 Introduction..................10 System Requirements................

11 Installing Invivo.................13 About the License Type.................. 13 Perpetual Licenses.................. 13 Network Licenses.................. 13 Internet Requirement...................

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13 Website Installation Instructions............... 13 InVivoDental Setup Wizard................ 14 Validating the Installer File.................

16 Feature List.................. Abb Doc Cat Software Download. 17 Software Layout.................18 Invivo Preferences................19 Display Preferences................... 19 Volume Rendering Preferences................. 21 File Manager Settings................... 22 Basic Features.................23 DICOM & Invivo File Loading with the File Manager............ 23 Invivo/DICOM File Saving.................

25 Invivo..................... 25 DICOM..................... 25 Custom Saving Dialog................... 26 Saving As an Invivo Project File................. 26 DICOM File Loading with PACS................

27 PACS Configuration.................. 27 PACS File Loading.................. 27 PACS File Saving................... 28 Export DICOM & Viewer.................. 28 Export to CD....................

29 Case Information Display.................. 30 Image Capture to File................... 30 Image Capture to Gallery.................. 31 Image Capture to an Email.................

31 Image Navigation................32 • I N V I V O 5. 4 ® – P I O N E E R I N G T H E N E W D I M E N S I O N O F P A T I E N T C A R E ™ ANA003 Rev B. 26 May 2015 Page 5 of 216 UM-INVEU-ENG-54B Slider Bar Scroll....................

32 Zoom In/Out.................... 32 Pan (Shift)..................... 32 Free Rotate..................... 33 Free Rolling..................... 33 Increment Rotate.................... 33 Increment Roll....................

33 Anatomical Plane Clipping.................. 34 Scroll Slice..................... 34 Move/Rotation Widget.................. 34 3D Restoration Widget.................. 34 Full Screen Mode and Keyboard Shortcuts...........35 Switching to Full Screen Mode................. 35 Keyboard Shortcuts at Volume Rendering View.............

35 The View Tabs.................36 Section View Features...............36 Section: Toolbar.................... 37 Section: Control Panel................... 38 Section: Rendering Window................. 40 Section: Airway Measurement................. 41 Section: Light Box................... 42 Volume Render View Features..............43 Volume Render: Toolbar..................

44 Volume Render: Control Panel................. 46 Volume Render: Patient Orientation................ 47 Volume Render: Render Window................ 48 Volume Render: Volume Measurements............... 49 Volume Render: Airway Measurement............... 50 Volume Render: Movie Capturing and Customized View Sequences........ 51 ArchSection View Features..............52 ArchSection: Toolbar...................

53 ArchSection: Control Panel.................. 55 ArchSection: Creating A Nerve Pathway............... 57 ArchSection: Rendering Window................ 58 Implant View Features...............59 Implant: Toolbar.................... 60 Implant: Control Panel...................

62 • I N V I V O 5. 4 ® – P I O N E E R I N G T H E N E W D I M E N S I O N O F P A T I E N T C A R E ™ ANA003 Rev B. 26 May 2015 Page 6 of 216 UM-INVEU-ENG-54B Implant: Rendering Window................. 64 Implant: View Preset Setup.................. 65 Implant: Model Visibility.................. 66 Implant: 3D Implant Widget.................

66 Implant: 2D Implant Widget................. 66 Implant: 3D Implant Planning................. 67 Implant: Pano Implant Planning................ 68 Implant: Bone Graft Simulation................. 69 Implant: Advanced Restoration Design...............

70 Implant: Adding Restorations................. 70 Implant: Check Sleeves.................. 71 Implant: View Sequencer.................. 72 Implant: Settings and Preferences................

74 Detailed Implant Settings................. 75 Preferred Implants Settings................ 75 Density Profile Control................. 76 Restoration View Features..............77 Restoration: Toolbar................... 78 Restoration: Control Panel.................

80 Restoration: Stone Model Registration............... 81 Restoration: Rendering Window & Mesh Manipulation............ 83 Restoration: View Preset Setup................. 84 Restoration: Abutment Planning................

85 Restoration: Abutment Planning Dialog............... 85 Abutment Parameters................. 85 Restoration: Crown Types.................. 87 Crowns for prepped teeth or custom abutments............ 87 Pontics..................... 87 Bridges..................... 88 Restoration: Articulation and Adjust Occlusion.............

89 TMJ View Features................90 TMJ: Toolbar..................... 91 TMJ: Control Panel................... 93 TMJ: Rendering Window.................. 94 Arch Spline (Focal Trough) Navigation.............. 94 TMJ: Layout..................... 95 Super Pano View Features...............96 • I N V I V O 5.

4 ® – P I O N E E R I N G T H E N E W D I M E N S I O N O F P A T I E N T C A R E ™ ANA003 Rev B. 26 May 2015 Page 7 of 216 UM-INVEU-ENG-54B Super Pano: Toolbar...................

97 Super Pano: Control Panel................. 98 Super Pano: Rendering Window................. 99 How to make a good Pano?................ 99 Super Ceph View Features..............100 Super Ceph: Toolbar.................. 101 Super Ceph: Control Panel................. 102 Super Ceph: Rendering Window................

103 Superimposition View Features.............104 Superimposition: Toolbar.................. 105 Superimposition: Control Panel................ 107 Superimposition: How to Superimpose Two Volumes............ 109 Superimposition: Using Superimposition Aligner for Fine Adjustments........

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111 Superimposition: Using Volume Registration for Fine Adjustments......... 112 Superimposition: Difference Between.vdata Files and.odata Files......... 114 Gallery View Features............... 115 Gallery: Toolbar.................... 116 Gallery: Control Panel.................. 116 Gallery: Rendering Window.................

117 Gallery: Adding Images to the Gallery............... 118 Gallery: 2D Image Options.................

120 Model View Features................ 121 Model: Toolbar.................... 122 Model: Control Panel.................. 124 Model: Rendering Window................. 125 Common How to Tasks...............126 How to Trace A Nerve..................

126 How to Create Reports In Life Size................ 127 Other View Tabs with Life-Size Printing............. 127 How to Create a Positive Airway View............... 128 How to Create an AnatoModel Simulation and Video........... 129 Invivo5 Additional Modules.............. 131 3DAnalysis Module Features..............132 3DAnalysis: Toolbar................... 133 3DAnalysis: Control Panel..................

135 3DAnalysis: Coordinate System................ 136 3DAnalysis: Tracing Tasks.................. 141 • I N V I V O 5. 4 ® – P I O N E E R I N G T H E N E W D I M E N S I O N O F P A T I E N T C A R E ™ ANA003 Rev B. 26 May 2015 Page 8 of 216 UM-INVEU-ENG-54B Tracing Task Examples and Tips............... 142 3DAnalysis: Text View..................

147 Colored Wigglegram................. 149 3DAnalysis: VCA Mode.................. 150 3DAnalysis: Advanced Analysis Configurations.............

154 Configuring a Frontal Analysis............... 154 Configuring a Sassouni Analysis............... 154 3DAnalysis: Create Face Photo................ 155 3DAnalysis: Landmark-Based Superimposition............. 157 Performing Landmark-Based Superimposition............

158 Superimposition Text View................ 159 How Does 3DAnalysis Work with the Superimposition Tab?........ 160 3DAnalysis: Layout Options................. 161 3DAnalysis: 3DAnalysis Settings................ 162 Special Landmark Properties................

165 3DAnalysis: Tracing Guide................. 173 3DAnalysis: Default Tracing Tasks and Landmarks............ 175 3DAnalysis: Save Information................

178 3DAnalysis: 3D Surgery Tool................. 180 3DAnalysis: Profilogram.................. 183 Report Module Features...............184 Report: Toolbar.................... 185 Report: Control Panel..................

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186 Report: Rendering Window................. 187 Report: Adding Text Controls.................

188 Report: Adding Slice Group Controls............... 191 Report: Adding Single Image Controls............... 193 Report: Image Type Definitions................

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194 Report: Slice Group Management................ 196 Adding Slices to a Group................ 197 Capturing Slices................... 198 Slice Control Selection Details................ 199 Report: Managing Templates.................

200 Report: Preferences................... 201 Report: Page Setup................... 202 Stitching Module Features..............203 Stitching: Toolbar................... 204 • I N V I V O 5. 4 ® – P I O N E E R I N G T H E N E W D I M E N S I O N O F P A T I E N T C A R E ™ ANA003 Rev B.

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26 May 2015 Page 9 of 216 UM-INVEU-ENG-54B Stitching: View Control.................. 205 Stitching: How to Stitch Two Volumes............... 206 Invivo5 Software Troubleshooting............. 211 Index...................

213 • I N V I V O 5. 4 ® – P I O N E E R I N G T H E N E W D I M E N S I O N O F P A T I E N T C A R E ™ ANA003 Rev B. 26 May 2015 Page 10 of 216 UM-INVEU-ENG-54B Introduction InVivoDental Imaging Software natomage, Inc. Is a medical imaging company composed of a cross-functional team consisting of the most elite researchers, mathematicians, engineers, software developers, business analysts, industry leaders, academic faculty, and dental specialists. We believe that InVivoDental software will enable the profession to initiate a revolution of unimaginable scope and magnitude. Ultimately, our mission is dedicated to developing software specially designed for dentists to be simple and refined, yet utilizing the most advanced cutting edge software and technology to better serve their patients. With InVivoDental software, doctors can create 3D volume renderings on their own computers, get cross sections, trace nerves, place implants, print images, save images, and many more functions.

The software is designed to reconstruct these 3D volume renderings from DICOM files generated by CBCT, Medical CT, and MRI radiography machines. InVivoDental is intended for use as a planning and simulation software in the placement of dental implants, orthodontics and surgical treatment. His manual is intended to provide supplementary information to your direct training with the Anatomage support team. For correct and safe use, training is available to all InVivoDental users and is highly recommended. In this document, InVivoDental refers to the latest version of the Anatomage InVivoDental software and is synonymous with the terms “Invivo” and “Invivo5.” Previously released versions of this manual are available. For more information on how to access previous versions of the InVivoDental Reference Manual, please contact the Anatomage customer support team at (408) 885-1474 or email [email protected] A T • I N V I V O 5. 4 ® – P I O N E E R I N G T H E N E W D I M E N S I O N O F P A T I E N T C A R E ™ ANA003 Rev B.

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26 May 2015 Page 11 of 216 UM-INVEU-ENG-54B System Requirements Below are the minimal and recommended system configurations. Aving an adequate computer system is essential to using InVivoDental efficiently and generating the highest quality images possible for enhanced analysis and presentation for your patients and colleagues. The most important element is the video card (3D graphics chip or GPU). If your system does not have an appropriate video card, you can purchase and install video cards for desktop computers. InVivoDental has minimal system requirements; however, Anatomage recommends the following configurations to fully utilize all the features within the InVivoDental Software.